Enjoy an epic 15-day journey on our Grand Heartland Cruise. This cruise on the Mississippi River travels from the northern reaches of St. Paul, MN all the way down to the basin in New Orleans.

View the dramatic landscapes of the Upper Mississippi River which have long inspired artists, writers, and steamboat passengers. Visit Hannibal, the hometown of Mark Twain where the characters in his most popular works come to life. Immerse yourself in the culture of Memphis, the mid-South's most vibrant city, famous for Blues and BBQ.

As you journey down the river, hear stories about southern life on the plantation and tour historic Civil War sites led by our local area experts. On your final stop, New Orleans, enjoy privileged access to its vibrant music scene and the best in Cajun and Creole cuisine.

Highlights


• Visit Mark Twain Boyhood Home. As you arrive in Hannibal, the boyhood home of famous author Mark Twain, relive the author’s experiences that heavily influenced his writings. Visit the actual home that Mark Twain grew up in, which is surrounded by the legendary whitewashed fence of Tom Sawyer.

• Enjoy National Eagle Center. Come face-to-face with bald and golden eagles at the National Eagle Center. This unique opportunity brings you within a few feet of these majestic creatures with no barrier between.

• Enjoy Deluxe Graceland Signature Tour. No trip to Memphis is complete without a trip to the home of the “King of Rock n’ Roll,” Elvis Presley. American Cruise Lines offers the most in-depth experience available at Graceland, allowing you to explore fascinating exhibits such as Elvis’ museum, estate grounds, the jungle and trophy rooms.

• Explore Vicksburg National Military Park. The night before our visit, our onboard Civil War historian gives a captivating lecture detailing all you are about to witness the next day at Vicksburg National Military Park.

• Enjoy Houmas House & Plantation Tour. The stately grandeur of Houmas House is complemented by its eclectic flair as our guide, Ms. Judy Davis who has a personality as magnificent as the mansion itself. Take a private tour through the gardens to the 16 room plantation home.

• Enjoy La Crosse Queen Eco Cruise. Cruise along the scenic Mississippi River on a classic paddlewheeler as your tour guide highlights the current and historical facts about the area and tests your knowledge with trivia along the way.

Each Mississippi itinerary comes complete with a Complimentary Pre-Cruise Package, providing you with a seamless way to board the ship and explore the local area. Arrive the day before your scheduled cruise date and American Cruise Lines will handle the rest. The package includes a premium hotel stay, where you can enjoy the city at your leisure. On the morning of the cruise, meet in the hotel lobby after breakfast and we will transport you to the ship to begin your cruise. All luggage will be brought directly from the hotel and placed in your stateroom aboard the ship. *Pre-Cruise Package is not available for reservations made within 30 days of cruise date.
St. Paul is a thrilling place to begin your adventure on the Mississippi River. History buffs will enjoy a walking tour of Summit Avenue, which showcases gorgeous historic mansions built in the late 1800’s. St. Paul’s enchanting art galleries, world class museums, and entertaining stage performances will capture your imagination.
Nestled among the scenic bluffs of the upper Mississippi River, Red Wing's beauty has inspired artisans and craftspeople for over 150 years. Red Wing delivers a diverse blend of arts, entertainment, and activities for your pleasure. Enjoy a show at the historic Sheldon Performing Arts Theatre or observe the beauty of nature at one of Red Wing’s 38 parks.
Step into 19th-century America in La Crosse, located on the banks of three captivating rivers. La Crosse is home to Riverside Park, where you can enjoy beautiful gardens, an outdoor performance center, and inspiring sculptures.
A “Masterpiece on the Mississippi,” Dubuque is among the oldest settlements west of the river. Take a ride on the Fenelon Place Elevator, the world’s shortest and steepest scenic railway, or try your luck in one of Dubuque's state-of-the-art casinos. View colorful Victorian mansions, stroll through the bustling downtown area, or visit the national Mississippi River Museum and Aquarium.
Voted one of the Most Livable Small Cities in America, Davenport is often described as a lively, active city with a hometown feel. The Legacy of John Deere, the largest agricultural exhibit in the world, resides here. Music enthusiasts will enjoy Davenport’s many festivals, including the Mississippi Valley Blues Festival, The Mississippi Valley Fair, and the Bix Beiderbecke Memorial Jazz Festival.
As we cruise from Davenport to Hannibal, enjoy the day relaxing on the upper deck or admiring the breathtaking view from your private balcony.
Hannibal, “America’s Hometown,” is a place where you can rediscover adventures from Mark Twain’s era. Tom Sawyer and Huck Finn come to life in this charming Missouri town, where you can run your hand along Aunt Polly’s fence, explore Injun Joe’s Cave, and get reacquainted with one of the world’s most beloved authors. The downtown area is a thriving haven for artisans, filled with specialty shops unique to Hannibal.
St. Louis is often referred to as the “Gateway to the West.” Take in the Gateway Arch Riverfront, highlighted by the Gateway Arch, the largest man-made monument in the U.S. Enjoy St. Louis' many world-class attractions, including the Art Museum, Science Center, Anheuser-Busch Brewery, and the Missouri History Museum. End your day by relaxing at the Missouri Botanical Garden, one of the world’s most popular public gardens.
Curl up with a good book in one of our spacious lounges, or grab a pair of binoculars and enjoy the fall foliage as we make our way down the Mississippi River.
Excitement resonates as you visit America’s third-largest inland port, famous for Blues, BBQ, and Elvis Presley's Graceland. The Memphis-Arkansas Memorial Bridge creates a dramatic backdrop this amazing city.
Spend a beautiful day with friends in one of the ship's comfortable lounges as we explore the river from Memphis to Vicksburg.
U.S. history is alive in Vicksburg. This “Queen City of the Bluff” offers plenty of opportunities to take a step back in time. Civil War battlefields, century old churches, cotton fields, and restored train depots are just a few of the many intriguing landmarks that await your visit. Marvel in the beautiful antebellum-style homes and learn about Vicksburg’s rich history as displayed on the riverfront murals.
Settled in 1716, Natchez is rich in history and southern hospitality. Enjoy a guided exploration of this fascinating city which has retained its antebellum charm since its surrender during the Civil War. Visit Frogmore, a historic cotton plantation still in use today, or attend a special piano concert in the J. N. Stone antebellum music room.
Experience the wonder of Baton Rouge, Louisiana's capital and one of the most historic and unforgettable cities in the South. Known as the Red Stick, Baton Rouge has everything you would expect to find in a state capital, but with a down-home flavor that is part of its charm.
Welcome back to New Orleans, the birthplace of Jazz. Culture and art abound around every corner of this unique city. The open-air artist colony proudly displays local works on the iron fence in Jackson Square, while the city’s 45 museums carefully preserve its rich history. Stay an extra day or more to enjoy the famed French Quarter.
Itineraries are subject to change.

AAR (Private Balcony). From

$ 10225 USD pp
AAR (Private Balcony). From
AAR staterooms on the main deck offer complete comfort with approximately 275 sq. ft. of living space. Enjoy a full-size bathroom, large picture window, and door leading out to a furnished private balcony. These staterooms also feature a large sitting area, ideal for getting together with friends.

AAL (Private Balcony). From

$ 11120 USD pp
AAL (Private Balcony). From
AAL staterooms can be found on the second deck and offer a luxurious 300 sq. ft. of living space. Each room is equipped with plush seating, full-size bathroom, and a private balcony with large sliding glass doors that offer great views of the Mississippi scenery. These staterooms are the epitome of comfort and relaxation.

AAC (Private Balcony). From

$ 11650 USD pp
AAC (Private Balcony). From
AAC staterooms are conveniently located on the third deck and offer all of the comforts of a fine hotel. Complete with a private balcony and floor-to-ceiling sliding glass doors, these staterooms provide spectacular views of the Mississippi River and the surrounding landscape. At 316 sq. ft., these staterooms also offer a sitting area, desk and full-size bathrooms.

AAM (Private Balcony). From

$ 12505 USD pp
AAM (Private Balcony). From
Located on the fourth deck, these spacious staterooms feature commanding views of the passing river landscapes. At 350 sq. ft., there is plenty of room to enjoy the tasteful comfort of your surroundings. These staterooms have all the comforts of a fine hotel and feature floor-to-ceiling sliding glass doors with a private balcony to offer panoramic views from every angle.

Single (Private Balcony). From

$ 12830 USD pp
Perfect for the solo traveler, our Single staterooms offer all of the amenities you expect from a fine hotel. At 250 sq. ft., these staterooms have spacious bathrooms and large sliding glass doors that lead to a private balcony.

Veranda Suite (Private Balcony). From

$ 13780 USD pp
Veranda Suite (Private Balcony). From
With a generous 405 sq. ft. of relaxing space, each Veranda suite includes a private walk-out balcony to enjoy the panoramic views. Considered one of the finest staterooms on any cruise ship, guests will enjoy full-size bathrooms and large living area with sliding glass door.

Owner's Suite (Private Balcony). From

$ 14935 USD pp
Owner's Suite (Private Balcony). From
Each Owner’s Suite offers the finest accommodations with unsurpassed views of the passing scenery. A spectacular 575 sq. ft. of space is your private sanctuary to spread out and make yourself at home. This spacious suite features a full-size bathroom, as well as a separate bedroom and living area. Floor-to-ceiling sliding glass doors let light pour in and allow private panoramic views from every vantage point. An expansive private balcony is a perfect place to savor a calm afternoon or to enjoy breakfast as the sun rises over the riverbank.

Grand Suite (Private Balcony). From

$ 17930 USD pp
Grand Suite (Private Balcony). From
The luxurious Grand Suite measures over 900 sq. ft. and offers 270◦ of panoramic views through floor-to-ceiling glass windows. Sliding glass doors lead out to a wrap-around balcony complete with a private dining area, the perfect place to enjoy breakfast room service or watch the sun set. Each Grand Suite features a separate bedroom and living area, ideal for gathering with family and friends after an invigorating day of exploration.

Additional charges:

Port taxes. From: 880 USD pp

American Harmony

Vessel Type: Riverboat

Passenger Capacity: 187

Built: 2018

The American River Cruise revolution continues with American Harmony, the newest ship in American Cruise Lines’ highly anticipated series of contemporary riverboats. These, the first modern riverboats ever in the U.S., have introduced many pioneering innovations to America’s waters. American Harmony will feature lounges soaring 40 feet above the water with triple the glass of other riverboats for astounding views. The new riverboat will also feature the Atrium, a four-story glass-enclosed area with a large domed skylight, which will serve as the central gathering point for the entire ship.

Our new suite design will allow for unprecedented comfort while traveling, beginning with the new Grand Suites featuring 900 square feet of private space. These spacious suites include two glass walls and a wraparound private balcony. Complimentary room service during select mealtimes is available for every stateroom, but the Grand Suites offer ample space to host small cocktail parties or private dinner events.

American Harmony will continue American Cruise Lines’ decade's long tradition for innovation in river cruising. With a capacity of just 187 guests, this new ship has the modern design features and contemporary styling that today’s traveler has come to expect. Experience the American Harmony for yourself next spring on the Mississippi River. 

Cabin layout for American Harmony
American Harmony
East Coast (USA) River BoatRiver Boat
15 Days from
$ 10225 USD pp

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